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UNIQUE ‘FIND AND TREAT’ TB SERVICE FOUND TO BE COST-EFFECTIVE

 

By Health Protection Agency

Thursday, 15 September 2011.

A mobile X-ray unit, which identifies people with Tuberculosis (TB) infection in hard to reach communities has proved a cost effective way of treating people with TB in London. These findings are  published in the British Medical Journal  and was presented yesterday at  be at the Health Protection Agency’s ( HPA) annual conference - Health Protection 2011 - at the University of Warwick.

The service visits locations where people at high risk of TB can be found, including drug treatment services and hostels or day centres for the homeless. All individuals found by the service are screened on a voluntary basis and, crucially, if they are infected they are followed up closely alongside hospital teams to support them in completing their treatment, which takes six months. Failure to complete treatment increases the risk of onward transmission as well as encouraging antibiotic resistance in the TB bacteria.

A total of 9,040 cases of TB were reported in the UK in 2009 with the majority of disease concentrated in urban areas. London accounted for 38 per cent of cases, with 3,440 cases reported to the HPA, equating to a rate of 44 per 100,000.

On average each year the find and treat service identifies 16 and manages 123 active tuberculosis cases in the hard-to-reach population. The service has a net cost of £1.4 million a year and gains at least 220 quality adjusted life years (QALYs). A QALY is a mathematical expression that scientists use to measure the health of a population.

The London-based ‘find and treat’ intervention costs around £6,400 to £10,000 for every year of life in good health which it provides the targeted population. This is usually regarded as an excellent use of NHS resources. Typically the NHS will fund interventions that cost less than £20,000 for every extra healthy year of life they provide.

Dr Peter White, a study author who is head of modelling and economics at the HPA and has an academic appointment at Imperial College London, said: “With TB numbers remaining high in London, the ‘find and treat’ programme was identified as a potential method of tackling the problem in these high risk populations. It has proved to be successful in identifying and offering treatment to those unaware they were infected with TB.”

Since September 2007 the tuberculosis find and treat service has been funded by the Department of Health with a mobile X-ray unit for active case finding, case holding and treatment completion support for hard-to-reach groups in London.

Research from 2003 found that hard-to-reach groups in London such as homeless people, problem drug users and prisoners were about 10 to 30 times more likely than the general London population to have TB. Since 2007 on average each year the ‘find and treat’ service identifies 16 people with TB in the hard-to-reach population, who may not have been identified and treated and also manages and supports the treatment for a further 100 or more cases.

Lead author, Dr Ibrahim Abubakar, head of the TB section at the HPA, said: “While this intervention alone will not reverse the rise in TB in London, it is likely to have an effect on the segment of the population with the greatest evidence of on-going transmission.

 “London has seen a resurgence of tuberculosis on a scale not seen in any other western European capital in the last two decades. The number of new cases of TB every year in the London Borough of Brent, London is comparable to that in Karonga district in Malawi. It is therefore appropriate that any intervention that provides a cost effective means to identify cases promptly and ensure that they complete treatment is an essential component of the tuberculosis control programme.”  

 

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